Vitamin D Helps Alleviate Heart Failure
Heart failure—the heart’s inability to pump enough blood to meet the body’s requirements—is a leading cause of death in industrialized nations. Scientists believe that elevated levels of circulating pro-inflammatory cytokines may contribute to heart failure, and that vitamin D may offer heart-protective benefits by quelling these inflammatory mediators.
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In a recent double-blind clinical trial, 123 patients with congestive heart failure were randomly assigned to receive either vitamin D3 (50 mcg [2000 IU] per day) plus 500 mg of calcium or placebo plus 500 mg of calcium.72 Over the nine months of the study, patients who supplemented with vitamin D had greatly increased levels of the anti-inflammatory cytokine interleukin-10 and lower levels of the pro-inflammatory cytokine tumor necrosis factor-alpha. Scientists believe that by reducing the inflammatory environment in congestive heart failure patients, vitamin D3 holds promise as an anti-inflammatory therapeutic for people suffering from heart failure.
A 2005 study reported on the use of vitamin D and other nutrients in chronic heart failure. In a randomized trial, 28 chronic heart failure patients supplemented with 200 IU of vitamin D, 150 mg of coenzyme Q10, minerals, antioxidants, and B vitamins or placebo for nine months. The supplemented patients had an impressive 17% decrease in the heart’s left ventricular volume, which typically is increased in chronic heart failure and adds to the work required of the already-fatigued heart muscle. By contrast, left ventricular volume increased 10% in the placebo group. Supplemented patients also had a modest increase in quality-of-life scores. These findings indicate that vitamin D supplementation, in combination with coenzyme Q10, vitamins, and minerals, can offer important support for people with chronic heart failure.